Project A01
Understanding plastin 3 and its interactors in motor neuron function and plasticity in health and disease
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![CRC1451_MotorControl_ResearchScheme_A01](https://www.crc1451.uni-koeln.de/wp-content/uploads/2021/02/CRC1451_MotorControl_ResearchScheme_A01.png)
Project A01 focuses on the mechanisms underlying motor neuron function and plasticity by investigating the protective role of Plastin 3 (PLS3) in a mouse model of spinal muscular atrophy (SMA). The protective effect of PLS3 will be further analysed in amyotrophic lateral sclerosis (ALS), a second motor neuron disease, to verify the cross-disease protective potency. Two putative pathomechanisms, i.e., disturbed Caveolin-dependent endocytosis and calcium homeostasis, will be investigated by molecular, cellular, and in vivo methods in genetically modified SMA and ALS mouse models, overexpressing PLS3.
![KPZ_4191](https://www.crc1451.uni-koeln.de/wp-content/uploads/2021/11/KPZ_4191-scaled-e1638099873673.jpg)
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Prof. Dr. Brunhilde Wirth
Principal Investigator
![KPZ_4193](https://www.crc1451.uni-koeln.de/wp-content/uploads/2021/11/KPZ_4193-scaled-e1638222423828.jpg)
©MedizinFotoKöln
Prof. Dr. Peter Kloppenburg
Principal Investigator