Project C03

Effects of progressive dopamine deficiency on networks engaged in vigorous volitional movements as encountered in compensated (prodromal) to decompensated (clinical stage) Parkinson’s disease will be explored. Structural and functional networks implicated in the planning and incentive salience of vigorous volitional movements will be investigated using a combination of computational phenotyping and molecular, functional, and structural neuroimaging technologies. The project will also probe dynamic network states, network topologies, and their efficacy associated with mitigation of motor deficits.