Project B01

Developmental mechanisms affecting motor skills and motor control

The influence of ion channel mutations on higher motor functions during brain maturation will be assessed in cortico – basal-ganglia – thalamus loops using genetic mouse models, c-Fos expression mapping, and in-vivo electrophysiological recordings combined with fibre photometry of dopaminergic axons. Besides, pharmacological and chemogenetic manipulations of neuronal activity will be tested timed to vulnerable windows of brain development, potentially leading to new treatment strategies for developmental disorders.

 

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Dirk Isbrandt

Principal Investigator

 

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Jochen Roeper

Principal Investigator

 

 

 

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Jacquelin Kasemir

PhD

 

 

 

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