Project B01
Developmental mechanisms
affecting motor skills and motor control
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The influence of ion channel mutations on higher motor functions during brain maturation will be assessed in cortico – basal-ganglia – thalamus loops using genetic mouse models, c-Fos expression mapping, and in-vivo electrophysiological recordings combined with fibre photometry of dopaminergic axons. Besides, pharmacological and chemogenetic manipulations of neuronal activity will be tested timed to vulnerable windows of brain development, potentially leading to new treatment strategies for developmental disorders.
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Prof. Dr. Dirk Isbrandt
Principal Investigator
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Prof. Dr. Jochen Roeper
Principal Investigator
Dr. Birgit Engeland
Postdoc
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Dr. Stephan MArguet
Postdoc
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Dr. Andrea Merseburg
Postdoc
Dr. Malte Stockebrand
Postdoc
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Dr. Pascal Vogel
Postdoc
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Jaquelin Kasemir
PhD
Thesis:
Developmental stage-specific analysis of molecular disease mechanisms in genetic epileptic encephalopathies
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Grusha Primal Mathias
PhD
Thesis:
Developmental mechanisms affecting motor skills and motor control
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Niklas Hammer
PhD
Thesis:
Projection-specific hierarchical organisation of somato-dendritic dopamine 2 receptor inhibition among midbrain dopamine neurons
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Daniela Schenkel
PhD
Thesis:
Characterization of an alpha-synuclein aggregate mouse model of PD