Project B01

Developmental mechanisms

affecting motor skills and motor control

©bestber; Shutterstock

The influence of ion channel mutations on higher motor functions during brain maturation will be assessed in cortico – basal-ganglia – thalamus loops using genetic mouse models, c-Fos expression mapping, and in-vivo electrophysiological recordings combined with fibre photometry of dopaminergic axons. Besides, pharmacological and chemogenetic manipulations of neuronal activity will be tested timed to vulnerable windows of brain development, potentially leading to new treatment strategies for developmental disorders.

 

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Prof. Dr. Dirk Isbrandt

Principal Investigator

 

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Prof. Dr. Jochen Roeper

Principal Investigator

 

Dr. Birgit Engeland

Postdoc

 

Dr. Stephan MArguet

Postdoc

 

Dr. Andrea Merseburg

Postdoc

 

Dr. Malte Stockebrand

Postdoc

 

Dr. Pascal Vogel

Postdoc

 

Jaquelin Kasemir

PhD

 

Thesis:
Developmental stage-specific analysis of molecular disease mechanisms in genetic epileptic encephalopathies

Grusha Primal Mathias

PhD

 

Thesis:
Developmental mechanisms affecting motor skills and motor control 

Niklas Hammer

PhD

 

Thesis:
Projection-specific hierarchical organisation of somato-dendritic dopamine 2 receptor inhibition among midbrain dopamine neurons

Daniela Schenkel

PhD

 

Thesis:
Characterization of an alpha-synuclein aggregate mouse model of PD

Pascal Vogel

PhD