Project A02

The role of the autophagy-endolysosome system
in Purkinje cell survival and the impact of its dysfunction on brain-wide motor circuits

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Project A02 investigates the role of the autophagy-endolysosomal system in the maintenance of voluntary motor control in the cerebellum and basal ganglia employing genetic mouse models. The project aims at elucidating whether voluntary motor control defects in mice lacking major endocytic complex AP-2 or crucial autophagy protein ATG5 are a result of their novel non-canonical roles in axonal trafficking and regulation of gene transcription.

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