Project A01: Understanding plastin 3 and its interactors in motor neuron function and plasticity in health and disease

Project A01 focuses on the mechanisms underlying motor neuron function and plasticity by investigating the protective role of Plastin 3 (PLS3) in a mouse model of spinal muscular atrophy (SMA). The protective effect of PLS3 will be further analysed in amyotrophic lateral sclerosis (ALS), a second motor neuron disease, to verify the cross-disease protective potency. Two putative pathomechanisms, i.e., disturbed Caveolin-dependent endocytosis and calcium homeostasis, will be investigated by molecular, cellular, and in vivo methods in genetically modified SMA and ALS mouse models, overexpressing PLS3.

 

Prof. Dr. Brunhilde Wirth | Principle Investigator

Institute of Human Genetics
University Hospital of Cologne
Kerpener Str. 34, D-50931 Köln

Phone: +49 221 478-86464
Fax: +49 221 478-86465

E-Mail: brunhilde.wirth@uk-koeln.de

 

Curriculum Vitae

Prof. Dr. rer. nat. Brunhilde Wirth
Center for Molecular Medicine Cologne

Publications

View publications by Prof. Dr. rer. nat. Brunhilde Wirth on ResearchGate

Neuroscience

Prof. Dr. rer. nat. Brunhilde Wirth
Head of Institute of Human Genetics