Project A01

Understanding plastin 3 and its interactors in motor neuron function and plasticity in health and disease

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Project A01 focuses on the mechanisms underlying motor neuron function and plasticity by investigating the protective role of Plastin 3 (PLS3) in a mouse model of spinal muscular atrophy (SMA). The protective effect of PLS3 will be further analysed in amyotrophic lateral sclerosis (ALS), a second motor neuron disease, to verify the cross-disease protective potency. Two putative pathomechanisms, i.e., disturbed Caveolin-dependent endocytosis and calcium homeostasis, will be investigated by molecular, cellular, and in vivo methods in genetically modified SMA and ALS mouse models, overexpressing PLS3.

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Prof. Dr. Brunhilde Wirth

Principal Investigator

 

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Prof. Dr. Peter Kloppenburg

Principal Investigator

 

Dr. Jan Erik Radermacher

Postdoc

 

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Tamas Schmidt

PhD

 

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Lisa Wolff

PhD

 

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Eleonora Zilio

PhD

 

Thesis:
Vesicular trafficking and axonal local translation in SMA – impact of the PLS3 protective modifier