Understanding plastin 3 and its interactors in motor neuron function and plasticity in health and disease
Project A01 focuses on the mechanisms underlying motor neuron function and plasticity by investigating the protective role of Plastin 3 (PLS3) in a mouse model of spinal muscular atrophy (SMA). The protective effect of PLS3 will be further analysed in amyotrophic lateral sclerosis (ALS), a second motor neuron disease, to verify the cross-disease protective potency. Two putative pathomechanisms, i.e., disturbed Caveolin-dependent endocytosis and calcium homeostasis, will be investigated by molecular, cellular, and in vivo methods in genetically modified SMA and ALS mouse models, overexpressing PLS3.
Prof. Dr. Brunhilde Wirth
Prof. Dr. Peter Kloppenburg
Dr. Jan Erik Radermacher
Vesicular trafficking and axonal local translation in SMA – impact of the PLS3 protective modifier