Research Area A

Identifying critical genes, molecules and networks

Project A01

Understanding plastin 3 and its interactors in motor neuron function and plasticity in health and disease

Project A01 focuses on the mechanisms underlying motor neuron function and plasticity by investigating the protective role of Plastin 3 (PLS3) in a mouse model of spinal muscular atrophy (SMA). The protective effect of PLS3 will be further analysed in amyotrophic lateral sclerosis (ALS), a second motor neuron disease, to verify the cross-disease protective potency. Two putative pathomechanisms, i.e., disturbed Caveolin-dependent endocytosis and calcium homeostasis, will be investigated by molecular, cellular, and in vivo methods in genetically modified SMA and ALS mouse models, overexpressing PLS3.

Brunhilde Wirth

Brunhilde Wirth

Principle Investigator

 

Institute of Human Genetics
University Hospital of Cologne
Kerpener Str. 34, Cologne

Phone: +49 221 478-86464
Fax: +49 221 478-86465
E-Mail: brunhilde.wirth@uk-koeln.de

Peter Kloppenburg

Peter Kloppenburg

Principle Investigator

 

Institute of Zoology , University of Cologne
CECAD Cluster of Excellence
Zülpicher Str. 47b, Cologne

Phone: +49 221 470-5950
E-Mail: peter.kloppenburg@
uni-koeln.de

Jan Erik Radermacher
Postdoc

Lisa Wolf
PhD student

Eleonora Zilio
PhD student

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